BDNF rs962369 Is Associated with Major Depressive Disorder

This study enrolled 291 patients diagnosed with depression and schizophrenia (F32, F33, F20 according to ICD-10) 227 ethnicity-matched control subjects. We analyzed the distribution of BDNF rs6265 rs962369 genotypes, finding no significant associations between these schizophrenia. revealed a increase in risk single-episode major disorder (MDD) for minor allele homozygotes (CC vs. TT+TC), an association that persisted after adjusting age sex (OR 3.47; 95% CI 1.36–8.85; p = 0.009). Furthermore, genotype was significantly associated increased recurrent MDD log-additive model per C-allele 1.65; 1.11–2.45; 0.013). A comparative analysis subtypes showed differences rs6265. Notably, frequency C varied across subgroups, highest (0.32) lowest (0.20). The presence genotypes at least one higher patient group compared group. In conclusion, variant but not